Article
Extensive variation in chromatin states across humans.
Science (New York, N.Y.) - 8 Nov 2013
Kasowski Maya, Kyriazopoulou-Panagiotopoulou Sofia, Grubert Fabian, Zaugg Judith B, Kundaje Anshul, Liu Yuling, Boyle Alan P, Zhang Qiangfeng Cliff, Zakharia Fouad, Spacek Damek V, Li Jingjing, Xie Dan, Olarerin-George Anthony, Steinmetz Lars M, Hogenesch John B, Kellis Manolis, Batzoglou Serafim, Snyder Michael
Abstract excerpt
The majority of disease-associated variants lie outside protein-coding regions, suggesting a link between variation in regulatory regions and disease predisposition. We studied differences in chromatin states using five histone modifications, cohesin, and CTCF in lymphoblastoid lines from 19 individuals of diverse ancestry. We found extensive signal variation in regulatory regions, which often switch between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.