Article
Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity, while contributing to health and disease in human populations
2018-10-16
Abstract excerpt
Regulatory DNA has the potential to be adaptive, and large numbers of expression quantitative trait loci (eQTLs) have recently been identified in humans. For the first time, a comprehensive study of adaptive eQTLs is possible. Many eQTLs have large allele frequency differences between populations, and these differences can be due to natural selection. Here, we combined population branch statistics with tissue-spec...
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Identifiers and source
- Literature Corpus work
- 6503fccf-d343-579e-ae20-93e6c057e037
- DOI
- 10.1101/444737