Article

Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML

2019-08-01

Abstract excerpt

DNMT3A R882 mutations are frequently observed in AML including the abundant R882H and the rare R882C, R882P and R882S. Using deep enzymology we show here that the DNMT3A-R882H has more than 70-fold altered flanking sequence preferences when compared with wildtype DNMT3A. The R882H flanking sequence preferences mainly differ on the 3’ side of the CpG site, where they resemble DNMT3B, while 5’ flanking sequence pref...

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Literature Corpus work: 71c02963-a031-5ddf-91b3-e031275b065f
DOI: 10.1101/721472

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