Article
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Nature communications - 3 Jul 2020
Gao Linfeng, Emperle Max, Guo Yiran, Grimm Sara A, Ren Wendan, Adam Sabrina, Uryu Hidetaka, Zhang Zhi-Min, Chen Dongliang, Yin Jiekai, Dukatz Michael, Anteneh Hiwot, Jurkowska Renata Z, Lu Jiuwei, Wang Yinsheng, Bashtrykov Pavel, Wade Paul A, Wang Gang Greg, Jeltsch Albert, Song Jikui
Abstract excerpt
Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning their...
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