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The DNMT3A R882H mutant displays altered flanking sequence preferences

27 Feb 2018

Abstract excerpt

The DNMT3A R882H mutation is frequently observed in acute myeloid leukemia (AML). It is located in the subunit and DNA binding interface of DNMT3A and has been reported to cause a reduction in activity and dominant negative effects. We investigated the mechanistic consequences of the R882H mutation on DNMT3A showing a roughly 40% reduction in overall DNA methylation activity. Biochemical assays demonstrated that...

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PMID: 29518238
DOI: 10.1093/nar/gky168

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