Article
The R736H cancer mutation in DNMT3A modulates the properties of the FF-subunit interface.
Biochimie - 1 May 2023
Kunert Stefan, Emperle Max, Adam Sabrina, Bräcker Julia, Brockmeyer Jens, Rajavelu Arumugam, Jeltsch Albert
Abstract excerpt
The DNMT3A DNA methyltransferase is an important epigenetic enzyme that is frequently mutated in cancers, particularly in AML. The heterozygous R736H mutation in the FF-interface of the tetrameric enzyme is the second most frequently observed DNMT3A cancer mutation, but its pathogenic mechanism is unclear. We show here that R736H leads to a moderate reduction in catalytic activity of 20-40% depending on the...
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