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Article

Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.

Journal of molecular biology - 15 Apr 2022

Mack Alexandra, Emperle Max, Schnee Philipp, Adam Sabrina, Pleiss Jürgen, Bashtrykov Pavel, Jeltsch Albert

Abstract excerpt

Somatic R882H DNMT3A mutations occur frequently in AML, but their pathogenic mechanism is unclear. As R882H mutations usually are heterozygous, wildtype (WT) and R882H subunits co-exist in affected cells. R882 is located in the RD interface of DNMT3A tetramers, which forms the DNA binding site. R882H causes strong changes in the flanking sequence preferences of DNMT3A. Here, we analyzed flanking sequence...

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Identifiers

PMID: 35131259
DOI: 10.1016/j.jmb.2022.167482

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Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.PMID 35131259Read ↗

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