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Article

DNMT3A-R882: a mutation with many paradoxes.

Annals of hematology - 1 Dec 2024

Jafari Pourya Arbab, Bagheri Ramin, Lavasani Soroush, Goudarzi Sajad

Abstract excerpt

Understanding the underlying mechanism of acute myeloid leukemia (AML) has led to the discovery of novel biomarkers to help predict, treat and monitor leukemia. DNA (cytosine-5)-methyltransferase 3 A (DNMT3A) is considered a prognostic and therapeutic epigenetic target in AML patients with a hotspot mutation of R882. R882 mutation is associated with impaired differentiation of Hematopoietic stem cells in the bone...

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Identifiers

PMID: 38969930
DOI: 10.1007/s00277-024-05874-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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