Article

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive <i>de novo</i> DNA methylation mechanisms

2020-04-29

Abstract excerpt

Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning their d...

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Literature Corpus work: 47e5b92b-5711-5c60-b969-64652006cead
DOI: 10.1101/2020.04.27.064386

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