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Article

Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.

Nature communications - 8 May 2020

Anteneh Hiwot, Fang Jian, Song Jikui

Abstract excerpt

DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA methylation during development. The R882H DNMT3A is a hotspot mutation in acute myeloid leukemia (AML) causing aberrant DNA methylation. However, how this mutation affects the structure and function of DNMT3A remains unclear. Here we report structural characterization of wild-type and R882H-mutated DNMT3A in complex with DNA substrates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32385248
DOI: 10.1038/s41467-020-16213-9
PMCID: PMC7210271

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