Article
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme.
Nucleic acids research - 17 Apr 2020
Norvil Allison B, AlAbdi Lama, Liu Bigang, Tu Yu Han, Forstoffer Nicole E, Michie Amie R, Chen Taiping, Gowher Humaira
Abstract excerpt
We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect of Arg882His in DNMT3A is not fully understood. Here, we discovered that DNMT3A WT enzyme under conditions that favor...
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