Article

Epigenetic Germline Variants Predict Cancer Prognosis and Risk and Distribute Uniquely in Topologically Associating Domains

2023-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Cancer is a highly heterogeneous disease caused by genetic and epigenetic alterations in normal cells. A recent study uncovered methylation quantitative trait loci (meQTLs) associated with different levels of local DNA methylation in cancers. Here, we investigated whether the distribution of cancer meQTLs reflected functional organization of the genome in the form of chromatin topologically asso...

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Literature Corpus work: 719b0119-53fa-5c96-92a1-a65ab82f2cf3
DOI: 10.1101/2023.07.04.547722

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