Article
Linkage of DNA methylation quantitative trait loci to human cancer risk.
Cell reports - 24 Apr 2014
Heyn Holger, Sayols Sergi, Moutinho Catia, Vidal Enrique, Sanchez-Mut Jose V, Stefansson Olafur A, Nadal Ernest, Moran Sebastian, Eyfjord Jorunn E, Gonzalez-Suarez Eva, Pujana Miguel Angel, Esteller Manel
Abstract excerpt
Epigenetic regulation and, in particular, DNA methylation have been linked to the underlying genetic sequence. DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts. We propose that interrogating the interplay between polymorphic alleles and DNA methylation is a powerful method for...
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