Article

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

2019-11-01

Abstract excerpt

<h4>Background</h4> Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). However, the advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified. <h4>Results</h4> We performed whole genome methyl-seq on diverse normal cells and tissues and three types of cancers (multiple m...

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Literature Corpus work: 41a5a20c-535f-5331-a007-b96aa991d434
DOI: 10.1101/815605

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