Article

The Shift from 2D to 3D Cell Culture in Neurobiology: Implications for Precision Medicine and Organ-on-Chip Technologies

2026-02-10

Abstract excerpt

<h4>Background: </h4> Traditional two-dimensional (2D) neurobiological models fail to capture the complex spatial, mechanical, and biochemical microenvironment of the human brain. This limitation has contributed to a high failure rate in translating neuroprotective drugs from bench to bedside. Main body: This review explores the technological evolution toward three-dimensional (3D) systems, including neural organo...

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Literature Corpus work: 0af08895-c6d6-5686-a79a-4232953bcd30
DOI: 10.20944/preprints202602.0738.v1

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