Article

Loss of age-associated increase in m <sup>6</sup> A-modified RNA contributes to GABAergic dysregulation in Alzheimer’s disease

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated RNA metabolism is a significant feature of Alzheimer’s disease (AD), yet how post-transcriptional RNA modifications like N 6 -methyladenosine (m 6 A) are altered in AD is unknown. Here, we performed d eamination a djacent to R NA modification targets (DART-seq) on human dorsolateral prefrontal cortices to assess changes in m 6 A with nucleotide resolution. In non-AD brains, m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71432fc6-0839-5f8c-9dbd-4583b310cce7
DOI: 10.1101/2025.05.02.651974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of age-associated increase in m <sup>6</sup> A-modified RNA contributes to GABAergic dysregulation in Alzheimer’s diseaseDOI 10.1101/2025.05.02.651974Read

Conserved reduction of m <sup>6</sup> A marks during aging and neurodegeneration is linked to altered translation of synaptic transcriptsSemantic proximity Read

Rewired m6A methylation of promoter antisense RNAs in Alzheimer’s disease regulates global gene transcription in the 3D nucleomeSemantic proximity Read

Isoform-level profiling of m6A epitranscriptomic signatures in human brainSemantic proximity Read

Reduced levels of N6-methyladenosine in RNA of peripheral blood mononuclear cells from patients with Alzheimer's diseaseSemantic proximity Read

Dynamics of N6-methyladenosine modification during Alzheimer's disease developmentSemantic proximity Read

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s diseaseSemantic proximity Read

DNA Adenine Methylation Clock in Brain Aging and Alzheimer’s Disease ProgressionSemantic proximity Read

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer’s Disease pathologySemantic proximity Read

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathySemantic proximity Read

Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the TherapeuticsSemantic proximity Read

RNA-seq variants reveal distinct patterns in the aging epitranscriptome: an in-depth analysis of age-matched Alzheimer’s Disease patients and a cognitively normal cohortSemantic proximity Read

Systematic identification of tissue-conserved m <sup>6</sup> A sites reveals a stable epitranscriptomic regulatory layer controlling essential genesSemantic proximity Read