Article

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s disease

2026-01-20

Abstract excerpt

Alzheimer’s disease (AD) is a deadly neurodegenerative disorder with no cure. It is associated with several dysregulated pathways, including axonal transport. The latter supplies synapses with several essential components, including proteins and mRNAs. A proportion of RNAs in neurons is transported from the soma to neuronal extensions along microtubules in highly organized structures, known as Neuronal RNA Granule...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05f22c5c-85ba-5f2c-b569-946e62fe28d4
DOI: 10.64898/2026.01.19.700388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s diseaseDOI 10.64898/2026.01.19.700388Read

RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme systemSemantic proximity Read

Loss of age-associated increase in m <sup>6</sup> A-modified RNA contributes to GABAergic dysregulation in Alzheimer’s diseaseSemantic proximity Read

Rewired m6A methylation of promoter antisense RNAs in Alzheimer’s disease regulates global gene transcription in the 3D nucleomeSemantic proximity Read

Dysregulation of RNA modification systems in clinical populations with neurocognitive disordersSemantic proximity Read

Reduced levels of N6-methyladenosine in RNA of peripheral blood mononuclear cells from patients with Alzheimer's diseaseSemantic proximity Read

Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the TherapeuticsSemantic proximity Read

Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the artSemantic proximity Read

Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain InjurySemantic proximity Read

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synucleinSemantic proximity Read

Dynamics of N6-methyladenosine modification during Alzheimer's disease developmentSemantic proximity Read

Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer’s Disease Mouse Model uncovered by PANDORA-seqSemantic proximity Read

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer’s Disease pathologySemantic proximity Read