Article

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer’s Disease pathology

2026-05-19

Abstract excerpt

Alternative mRNA splicing and post-transcriptional RNA modification are key mechanisms that regulate transcript function; however, their role in neuronal activity and neurodegenerative disease remains poorly defined. In this study, we evaluated two nanopore-based long-read sequencing (LR-seq) formats: cDNA-PCR sequencing (CPS) and direct RNA sequencing (DRS). We then applied DRS to profile both full-length isoform...

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Literature Corpus work: 63a3a163-3369-53ae-bb8e-cfe6c069d6c1
DOI: 10.64898/2026.05.18.724443

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