Article

DNA Adenine Methylation Clock in Brain Aging and Alzheimer’s Disease Progression

2026-03-06

Abstract excerpt

N 6 -methyldeoxyadenosine (N 6 medA) is a recently identified endogenous DNA modification widely found in bacteria, plants, and eukaryotes. In mammals, N 6 medA has been implicated in brain function, immunity, and response to environmental stress, but its relevance to gene regulation and mammalian aging remains controversial due to its extremely low abundance (< 1 per 10 million adenines) and an uncertainty reg...

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Literature Corpus work: eebd9894-b78b-5e53-a1d2-1640acf1d331
DOI: 10.64898/2026.03.05.709867

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