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Conserved reduction of m <sup>6</sup> A marks during aging and neurodegeneration is linked to altered translation of synaptic transcripts

2022-06-10

Abstract excerpt

N 6 -methyladenosine (m 6 A) plays diverse roles in the regulation of mRNA metabolism. In the mammalian brain it has been linked to developmental processes and memory function. However, the precise role of m 6 A in the context synaptic plasticity and especially during impaired cognition are not fully understood. Here, we describe the mouse and human brain m 6 A epi-transcriptome in a tissue-specific manner. We...

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Literature Corpus work
0a1dbef7-aeef-528a-82ef-a2de5b898756
DOI
10.1101/2022.06.08.495100
Open publication

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Conserved reduction of m <sup>6</sup> A marks during aging and neurodegeneration is linked to altered translation of synaptic transcriptsDOI 10.1101/2022.06.08.495100
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