Article
Clonal dynamics and somatic evolution of haematopoiesis in mouse
2024-09-21
Abstract excerpt
Haematopoietic stem cells maintain blood production throughout life. While extensively characterised using the laboratory mouse, little is known about how the population is sustained and evolves with age. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1845 single cell-derived colonies, and used phylogenetic analysis to infer the ontogeny and pop...
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Identifiers and source
- Literature Corpus work
- 712c53d9-9f7d-506f-9988-c7669a544fb2
- DOI
- 10.1101/2024.09.17.613129