Clonal dynamics and somatic evolution of haematopoiesis in mouse.

doi:10.1038/s41586-025-08625-8

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Article

Clonal dynamics and somatic evolution of haematopoiesis in mouse.

Nature - 1 May 2025

Kapadia Chiraag D, Williams Nicholas, Dawson Kevin J, Watson Caroline, Yousefzadeh Matthew J, Le Duy, Nyamondo Kudzai, Kodavali Sreeya, Cagan Alex, Waldvogel Sarah, Zhang Xiaoyan, De La Fuente Josephine, Leongamornlert Daniel, Mitchell Emily, Florez Marcus A, Sosnowski Krzysztof, Aguilar Rogelio, Martell Alejandra, Guzman Anna, Harrison David, Niedernhofer Laura J, King Katherine Y, Campbell Peter J, Blundell Jamie, Goodell Margaret A, Nangalia Jyoti

Abstract excerpt

Haematopoietic stem cells maintain blood production throughout life1. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse...

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PMID: 40044850
DOI: 10.1038/s41586-025-08625-8
PMCID: PMC12074984

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