Article
Clonal hematopoiesis in human aging and disease.
Science (New York, N.Y.) - 1 Nov 2019
Jaiswal Siddhartha, Ebert Benjamin L
Abstract excerpt
As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal...
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