Article

The T2R38 bitter taste receptor as a modifier of host response to Pseudomonas aeruginosa infection in cystic fibrosis

2019-01-01

Abstract excerpt

Rationale: Heterogeneity in cystic fibrosis (CF) lung disease is greater than can be explained by variability at the cystic fibrosis transmembrane conductance regulator (CFTR) locus, suggesting the involvement of modifier genes. The T2R38 (taste receptor 2, member 38) bitter taste receptor on respiratory epithelia detects Pseudomonas aeruginosa (Pa) N-acyl-L-homoserine lactones (AHLs). T2R38 activation leads to in...

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Literature Corpus work: 70e5db55-62bc-55ab-bc70-da28ffb117a9
DOI: 10.25560/68734

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