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Article

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention.

International forum of allergy & rhinology - 1 Mar 2013

Adappa Nithin D, Howland Timothy J, Palmer James N, Kennedy David W, Doghramji Laurel, Lysenko Anna, Reed Danielle R, Lee Robert J, Cohen Noam A

Abstract excerpt

BACKGROUND: We recently demonstrated the bitter taste receptor T2R38 upregulates sinonasal mucosal innate defense in response to gram-negative quorum-sensing molecules through increased nitric oxide production and mucociliary clearance. T2R38 was initially identified in the quest to understand the variability in bitter taste perception to the compound phenylthiocarbamide (PTC) and demonstrated to have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23322450
DOI: 10.1002/alr.21140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention.PMID 23322450Read ↗

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