Article
Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention.
International forum of allergy & rhinology - 1 Mar 2013
Adappa Nithin D, Howland Timothy J, Palmer James N, Kennedy David W, Doghramji Laurel, Lysenko Anna, Reed Danielle R, Lee Robert J, Cohen Noam A
Abstract excerpt
BACKGROUND: We recently demonstrated the bitter taste receptor T2R38 upregulates sinonasal mucosal innate defense in response to gram-negative quorum-sensing molecules through increased nitric oxide production and mucociliary clearance. T2R38 was initially identified in the quest to understand th...
Topics
- Adult
- Antigens, Bacterial
- Chronic Disease
- Female
- Genotype
- Gram-Negative Bacteria
- Gram-Negative Bacterial Infections
- Humans
- Immunity, Innate
- Male
- Middle Aged
- Mucociliary Clearance
- Nasal Mucosa
- Nitric Oxide
- Polymorphism, Genetic