Article
The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis.
The Laryngoscope - 1 Jan 2017
Cohen Noam A
Abstract excerpt
OBJECTIVE: Chronic rhinosinusitis (CRS) refractory to therapeutic intervention may involve a particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the microbial process of quorum sensing whereby microbes secrete factors that regulate the expression of microbial genes involved in biofilm formation, persistence, and virulence. Here, we review recent work demonstrating that...
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