Article
The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis.
The Laryngoscope - 1 Jan 2017
Cohen Noam A
Abstract excerpt
OBJECTIVE: Chronic rhinosinusitis (CRS) refractory to therapeutic intervention may involve a particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the microbial process of quorum sensing whereby microbes secrete factors that regulate the expression of mic...
Topics
- Biofilms
- Cells, Cultured
- Chronic Disease
- Cilia
- Fluorescent Antibody Technique
- Genotype
- Humans
- Immunity, Innate
- Microscopy, Confocal
- Microscopy, Electron, Scanning
- Mucociliary Clearance
- Polymorphism, Single Nucleotide
- Receptors, G-Protein-Coupled
- Respiratory Tract Infections
- Rhinitis
- Sinusitis
- Taste Receptors, Type 2