Article
T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients.
International forum of allergy & rhinology - 1 Apr 2016
Adappa Nithin D, Workman Alan D, Hadjiliadis Denis, Dorgan Daniel J, Frame Danielle, Brooks Steven, Doghramji Laurel, Palmer James N, Mansfield Corrine, Reed Danielle R, Cohen Noam A
Abstract excerpt
BACKGROUND: Chronic rhinosinusitis (CRS) is very prevalent in the cystic fibrosis (CF) patient population, and leads to high morbidity and markedly decreased quality of life (QOL). Identification of genetic markers that contribute to CRS symptoms in these patients can allow for risk stratification and tailoring of medical and surgical treatments. T2R38 is a bitter taste receptor expressed in the sinonasal tract,...
Topics
- Adolescent
- Adult
- Chronic Disease
- Cystic Fibrosis
- Female
- Genotype
- Humans
- Male
- Quality of Life
- Receptors, G-Protein-Coupled
- Rhinitis