Article
Genotype-specific regulation of oral innate immunity by T2R38 taste receptor.
Molecular immunology - 1 Dec 2015
Gil Sucheol, Coldwell Susan, Drury Jeanie L, Arroyo Fabiola, Phi Tran, Saadat Sanaz, Kwong Danny, Chung Whasun Oh
Abstract excerpt
The bitter taste receptor T2R38 has been shown to regulate mucosal innate immune responses in the upper airway epithelium. Furthermore, SNPs in T2R38 influence the sensitivity to 6-n-propylthiouracil (PROP) and are associated with caries risk/protection. However, no study has been reported on the role of T2R38 in the innate immune responses to oral bacteria. We hypothesize that T2R38 regulates oral innate...
Topics
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Epithelial Cells
- Genotype
- Gingiva
- Humans
- Immunity, Innate
- Immunity, Mucosal
- Interleukin-1alpha
- Interleukin-8
- Polymerase Chain Reaction