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Article

Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease.

International journal of molecular sciences - 17 Feb 2017

Douglas Jennifer E, Cohen Noam A

Abstract excerpt

The bitter taste receptor T2R38 has been shown to play a role in the pathogenesis of chronic rhinosinusitis (CRS), where the receptor functions to enhance upper respiratory innate immunity through a triad of beneficial immune responses. Individuals with a functional version of T2R38 are tasters for the bitter compound phenylthiocarbamide (PTC) and exhibit an anti-microbial response in the upper airway to certain...

Topics

Animals
Biofilms
Genetic Variation
Humans
Immunity, Innate
Paranasal Sinuses
Respiratory Tract Diseases
Taste Buds

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28218655
DOI: 10.3390/ijms18020437
PMCID: PMC5343971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28218655-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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