Article
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.
The Journal of clinical investigation - 1 Nov 2012
Lee Robert J, Xiong Guoxiang, Kofonow Jennifer M, Chen Bei, Lysenko Anna, Jiang Peihua, Abraham Valsamma, Doghramji Laurel, Adappa Nithin D, Palmer James N, Kennedy David W, Beauchamp Gary K, Doulias Paschalis-Thomas, Ischiropoulos Harry, Kreindler James L, Reed Danielle R, Cohen Noam A
Abstract excerpt
Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized p...
Topics
- Cell Line
- Female
- Genetic Predisposition to Disease
- Humans
- Immunity, Innate
- Male
- Nasal Mucosa
- Paranasal Sinuses
- Polymorphism, Genetic
- Pseudomonas Infections