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Article

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.

The Journal of clinical investigation - 1 Nov 2012

Lee Robert J, Xiong Guoxiang, Kofonow Jennifer M, Chen Bei, Lysenko Anna, Jiang Peihua, Abraham Valsamma, Doghramji Laurel, Adappa Nithin D, Palmer James N, Kennedy David W, Beauchamp Gary K, Doulias Paschalis-Thomas, Ischiropoulos Harry, Kreindler James L, Reed Danielle R, Cohen Noam A

Abstract excerpt

Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized primary human sinonasal cells, we demonstrate that T2R38 is expressed in human upper respiratory epithelium and is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Polymorphism, Genetic

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Share to Receptors, G-Protein-Coupled

Share to Taste Receptors, Type 2

Source

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Identifiers

PMID: 23041624
DOI: 10.1172/JCI64240
PMCID: PMC3484455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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