Article

Generative AAV capsid diversification by latent interpolation

2021-04-17

Abstract excerpt

<h4>Summary</h4> Adeno-associated virus (AAV) capsids have shown clinical promise as delivery vectors for gene therapy. However, the high prevalence of pre-existing immunity against natural capsids poses a challenge for widespread treatment. The generation of diverse capsids that are potentially more capable of immune evasion is challenging because introducing multiple mutations often breaks capsid assembly. Here...

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Literature Corpus work: a421cf44-d243-59a0-bc52-b4d3a5ff240e
DOI: 10.1101/2021.04.16.440236

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