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Article

Receptor Switching in Newly Evolved Adeno-associated Viruses.

Journal of virology - 9 Sept 2021

Havlik L Patrick, Das Anshuman, Mietzsch Mario, Oh Daniel K, Ark Jonathan, McKenna Robert, Agbandje-McKenna Mavis, Asokan Aravind

Abstract excerpt

Adeno-associated viruses utilize different glycans and the AAV receptor (AAVR) for cellular attachment and entry. Directed evolution has yielded new AAV variants; however, structure-function correlates underlying their improved transduction are generally overlooked. Here, we report that infectious cycling of structurally diverse AAV surface loop libraries yields functionally distinct variants. Newly evolved...

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Identifiers

PMID: 34232726
DOI: 10.1128/JVI.00587-21
PMCID: PMC8428401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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