The Role of Thermal Stability in AAV Titration of Engineered Variants

Abstract excerpt

<h4>ABSTRACT</h4> Determining the concentration of recombinant adeno-associated virus (AAV) productions, also known as titering, is crucial not only for quality control purposes but also for comparative studies of preclinical and clinical gene therapy trials. Recently, several AAVs were engineered by inserting seven amino acids at the outermost tip of the capsid’s protruding VR-VIII loop. These variants have demo...

Topics

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• Animal Virus Infections Studies
• CAR-T cell therapy research
• Respiratory viral infections research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

eb1f19b2-c296-511b-973b-250b8ccc457e

DOI

10.1101/2024.09.11.612416