Article

Fully functional AAV viral vectors with highly altered structural cores and subunit interfaces using ProteinMPNN

2025-07-26

Abstract excerpt

Adeno-associated viruses (AAV) have emerged as a viable vector for gene therapy, with several clinical approvals and a growing pipeline in clinical trials. These vectors have several challenges that need to be addressed to widen their use, including improving tropisms, reducing manufacturing costs, increasing storage stability, minimising their immunogenicity, or evasion of existing AAV immunity in which neutralis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bf5edf4-013c-5066-9533-cf6d990f9c5e
DOI: 10.1101/2025.07.24.666527

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fully functional AAV viral vectors with highly altered structural cores and subunit interfaces using ProteinMPNNDOI 10.1101/2025.07.24.666527Read

Multiparametric domain insertional profiling of Adeno-Associated Virus VP1Semantic proximity Read

Multiparametric domain insertional profiling of adeno-associated virus VP1Semantic proximity Read

Systematic multi-trait AAV capsid engineering for efficient gene deliverySemantic proximity Read

Adeno-Associated Virus Structural Biology as a Tool in Vector DevelopmentSemantic proximity Read

Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine LearningSemantic proximity Read

Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehiclesSemantic proximity Read

Insidious Insights: Implications of viral vector engineering for pathogen enhancementSemantic proximity Read

Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus ProductionSemantic proximity Read

rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations.Semantic proximity Read

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.Semantic proximity Read

Tailoring the AAV vector capsid for gene therapy.Semantic proximity Read

Progress in Bioengineering of Myotropic Adeno-Associated Viral Gene Therapy VectorsSemantic proximity Read