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Article

A higher-order entity formed by the flexible assembly of RAP1 with TRF2

8 Jan 2016

Abstract excerpt

Telomere integrity is essential to maintain genome stability, and telomeric dysfunctions are associated with cancer and aging pathologies. In human, the shelterin complex binds TTAGGG DNA repeats and provides capping to chromosome ends. Within shelterin, RAP1 is recruited through its interaction with TRF2, and TRF2 is required for telomere protection through a network of nucleic acid and protein interactions....

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PMID: 26748096
DOI: 10.1093/nar/gkv1531

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