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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres

23 Aug 2025

Abstract excerpt

The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1, and RAP1) that can assemble into various subcomplexes in vitro, but their stoichiometry and dynamics in cells remain poorly understood. To quantitatively analyze shelterin function, we generated a panel of human cancer cell lines...

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Share to Chromosomal and Genetic Variations
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 40849907
DOI: 10.1016/j.celrep.2025.116178

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