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Article

In Vivo Stoichiometry of Shelterin Components

30 Oct 2009

Abstract excerpt

Human telomeres bind shelterin, the six-subunit protein complex that protects chromosome ends from the DNA damage response and regulates telomere length maintenance by telomerase. We used quantitative immunoblotting to determine the abundance and stoichiometry of the shelterin proteins in the chromatin-bound protein fraction of human cells. The abundance of shelterin components was similar in primary and...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19864690
DOI: 10.1074/jbc.m109.038026

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