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Article

Characterization of the DNA binding specificity of Shelterin complexes

18 Aug 2011

Abstract excerpt

The Shelterin complex associates with telomeres and plays an essential role in telomere protection and telomerase regulation. In its most abundant form, the complex is composed of six core components: TRF1, TRF2, POT1, TIN2, TPP1 and RAP1. Of these subunits, three can interact directly with either single-stranded (POT1) or double-stranded (TRF1, TRF2) telomeric DNA. In this report, we have developed assays to...

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Share to DNA Repair Mechanisms
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PMID: 21852327
DOI: 10.1093/nar/gkr665

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