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Article

The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.

Nucleic acids research - 20 Aug 2021

Liu Jinqiang, Hu Xichan, Bao Kehan, Kim Jin-Kwang, Zhang Catherine, Jia Songtao, Qiao Feng

Abstract excerpt

Shelterin is a six-protein complex that coats chromosome ends to ensure their proper protection and maintenance. Similar to the human shelterin, fission yeast shelterin is composed of telomeric double- and single-stranded DNA-binding proteins, Taz1 and Pot1, respectively, bridged by Rap1, Poz1 and Tpz1. The assembly of the proteinaceous Tpz1-Poz1-Rap1 complex occurs cooperatively and disruption of this shelterin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34255844
DOI: 10.1093/nar/gkab550
PMCID: PMC8373121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.PMID 34255844Read ↗

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

Shelterin is a Dimeric Complex with Extensive Structural HeterogeneitySemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Shelterin is a dimeric complex with extensive structural heterogeneitySemantic proximity Read ↗

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeresSemantic proximity Read ↗

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.Semantic proximity Read ↗

A higher-order entity formed by the flexible assembly of RAP1 with TRF2Semantic proximity Read ↗

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1Semantic proximity Read ↗

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.Semantic proximity Read ↗

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