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Article

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.

Cell reports - 29 Sept 2015

Liu Jinqiang, Yu Clinton, Hu Xichan, Kim Jin-Kwang, Bierma Jan C, Jun Hyun-Ik, Rychnovsky Scott D, Huang Lan, Qiao Feng

Abstract excerpt

Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here, we have developed a strategy, called MICro-MS (Mapping Interfaces via Crosslinking-Mass Spectrometry), that combines crosslinking-mass spectrometry and phylogenetic analysis to identify contact sites within the complex. This strategy allowed identification of separation-of-function...

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Source

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Identifiers

PMID: 26365187
DOI: 10.1016/j.celrep.2015.08.043
PMCID: PMC4591219

Genes

POT1
TPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.PMID 26365187Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.Semantic proximity Read ↗

Human shelterin protein POT1 prevents severe telomere instability induced by homology-directed DNA repair.Semantic proximity Read ↗

The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.Semantic proximity Read ↗

Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood.Semantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

Shelterin is a Dimeric Complex with Extensive Structural HeterogeneitySemantic proximity Read ↗

Active telomere elongation by a subclass of cancer-associated POT1 mutations.Semantic proximity Read ↗

Shelterin is a dimeric complex with extensive structural heterogeneitySemantic proximity Read ↗

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