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Article

The shelterin complex and hematopoiesis.

The Journal of clinical investigation - 2 May 2016

Jones Morgan, Bisht Kamlesh, Savage Sharon A, Nandakumar Jayakrishnan, Keegan Catherine E, Maillard Ivan

Abstract excerpt

Mammalian chromosomes terminate in stretches of repetitive telomeric DNA that act as buffers to avoid loss of essential genetic information during end-replication. A multiprotein complex known as shelterin prevents recognition of telomeric sequences as sites of DNA damage. Telomere erosion contributes to human diseases ranging from BM failure to premature aging syndromes and cancer. The role of shelterin telomere...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27135879
DOI: 10.1172/JCI84547
PMCID: PMC4855927

Genes

ACD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The shelterin complex and hematopoiesis.PMID 27135879Read ↗

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Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita.Semantic proximity Read ↗

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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organizationSemantic proximity Read ↗

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