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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of <i>ERAP2</i> transcripts under balancing selection

2017-09-14

Abstract excerpt

While the impact of common genetic variants on gene expression response to cellular stimuli has been analyzed in depth, less is known about how stimulation modulates the genetic control of isoform usage. Analyzing RNA-seq profiles of monocyte-derived dendritic cells from 243 individuals, we uncovered thousands of unannotated isoforms synthesized in response to viral infection and stimulation with type I interferon...

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Literature Corpus work
70909a6a-359d-5e2e-bf49-c73c7bcb58bf
DOI
10.1101/188961
Open publication

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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of <i>ERAP2</i> transcripts under balancing selectionDOI 10.1101/188961
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