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Article

Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.

Science (New York, N.Y.) - 26 Nov 2021

Randolph Haley E, Fiege Jessica K, Thielen Beth K, Mickelson Clayton K, Shiratori Mari, Barroso-Batista João, Langlois Ryan A, Barreiro Luis B

Abstract excerpt

Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type specific. Higher levels of European ancestry are...

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Source

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Identifiers

PMID: 34822289
DOI: 10.1126/science.abg0928
PMCID: PMC8957271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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