Article

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

2018-05-11

Abstract excerpt

Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have now been mapped in multiple cell types and conditions, the molecular mechanisms through which these variants exert their effect have remained elusive. Specifically, changes in transcript usage could arise from promoter choice, alternati...

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Literature Corpus work: 0db9c0d0-900f-5660-838e-f4ad6afd9249
DOI: 10.1101/319806

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