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Article

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Cell - 20 Oct 2016

Quach Hélène, Rotival Maxime, Pothlichet Julien, Loh Yong-Hwee Eddie, Dannemann Michael, Zidane Nora, Laval Guillaume, Patin Etienne, Harmant Christine, Lopez Marie, Deschamps Matthieu, Naffakh Nadia, Duffy Darragh, Coen Anja, Leroux-Roels Geert, Clément Frederic, Boland Anne, Deleuze Jean-François, Kelso Janet, Albert Matthew L, Quintana-Murci Lluis

Abstract excerpt

Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses and their genetic and evolutionary determinants remain undefined. Here, we characterized, using RNA sequencing, the transcriptional response of primary monocytes from Africans and Europeans to bacterial and viral stimuli-ligands activating Toll-like receptor pathways...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27768888
DOI: 10.1016/j.cell.2016.09.024
PMCID: PMC5075285

Genes

TLR1
TLR4
TLR7

Provenance

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