Article

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 (NR4A2)

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make dopamine and degenerates in Parkinson’s disease. Recently, we demonstrated that Nurr1 binds directly to and is regulated by the endogenous dopamine...

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Literature Corpus work: 70576a98-0b88-525b-b097-d48bee756487
DOI: 10.1101/2021.05.09.442997

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