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Article

Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1.

ACS chemical biology - 16 Jul 2021

Kholodar Svetlana A, Lang Geoffrey, Cortopassi Wilian A, Iizuka Yoshie, Brah Harman S, Jacobson Matthew P, England Pamela M

Abstract excerpt

The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make dopamine and degenerates in Parkinson's disease. Recently, we demonstrated that Nurr1 binds directly to and is regulated by the endogenous dopamine metabolite...

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Identifiers

PMID: 34165961
DOI: 10.1021/acschembio.1c00326
PMCID: PMC9064169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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