Article
NURR1 mutations in cases of schizophrenia and manic-depressive disorder.
American journal of medical genetics - 4 Dec 2000
Buervenich S, Carmine A, Arvidsson M, Xiang F, Zhang Z, Sydow O, Jönsson E G, Sedvall G C, Leonard S, Ross R G, Freedman R, Chowdari K V, Nimgaonkar V L, Perlmann T, Anvret M, Olson L
Abstract excerpt
Transgenic mice lacking the nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) fail to develop mesencephalic dopamine neurons. There is a highly homologous NURR1 gene in humans (formerly known as NOT) which therefore constitutes a good candidate gene for neurologic and psychiatric disorders with an involvement of the dopamine neuron system, such as Parkinson's disease, schizophrenia, and...
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