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Article

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

1 Mar 2001

Abstract excerpt

The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine-synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the maintenance, as well as development, of the dopaminergic phenotype. To address this issue, we...

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PMID: 11238740
DOI: 10.1046/j.1471-4159.2001.00181.x

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