Article
Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.
Molecular and cellular neurosciences - 1 May 1998
Castillo S O, Baffi J S, Palkovits M, Goldstein D S, Kopin I J, Witta J, Magnuson M A, Nikodem V M
Abstract excerpt
To ascertain the function of an orphan nuclear receptor Nurr1, a transcription factor belonging to a large gene family that includes receptors for steroids, retinoids, and thyroid hormone, we generated Nurr1-null mice by homologous recombination. Mice, heterozygous for a single mutated Nurr1 alle...
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